Guzzo graduated from University of Notre Dame and St. Louis University School of Medicine. He trained in Nephrology at the University of Pennsylvania. He was Chief of the Division of Nephrology at Lehigh Valley Hospital for 25 years and is Medical Director of Bethlehem Kidney Clinic. Guzzo is an Associate Professor of Medicine for Morsani College of Medicine, University of South Florida. Guzzo joined Valley Kidney Specialists, PC in 1979 and is Board Certified in Nephrology and Internal Medicine by the American Board of Internal Medicine.